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In 2010 the autism phenomenon reached worrying dimensions with reports of one case per hundred children (1:100) in the USA. Findings indicate the influence of genetic factors associated with environmental aspects. The assumption is that as the population grows, new mutations emerge in the human genome, adhering to the polymorphs of the chromosomes A or B and contributing to the development of the autistic syndrome. It is still not possible to isolate and distinguish genetic, environmental and neuro-developmental factors. Children are recently diagnosed at an early age (two years) but even this age may be too late since the critical stage at which it is still possible to significantly influence development is in infancy. The advantage of diagnosis during infancy stems from the dynamism of the brain at this stage. The most accelerated growth of neurons occurs in the first 18 months of life, creating a complex texture of cells that control the baby's sensory-emotional-cognitive regulation. A study conducted over the last decade concerning early treatment intervention for autism – examined 110 babies who were diagnosed with autism at the age of two-three years, using retrospective analysis of video-recording of the first months of their lives by their parents. In the video-records of 98 of the babies it was possible to identify early signs which pointed to autism characteristics and which were often sufficiently minor to be unnoticed by parents. Findings for six of the babies also showed pathological (physio-neurological) indices. In several cases, parents discerned problems but did not think them especially important, or were reassured that nothing was wrong by people in their environment. As a result of this study, the Mifne Center developed a scale to identify indices associated with autistic characteristics in the first year of life – ESPASI, the signs relate to continuous attachment and non-verbal difficulties during the first year of life. This scale is used now at the some pioneer units for detection of Infants at risk in several medical centers. Identification and treatment in the first year of life can alter the process of development for a baby that exhibits difficulties in sensory regulation and creation of bonding, and minimize the development of autism.